CALP1 (trifluoroacetate salt)

Formulation: A crystalline solid

Formal Name: L-valyl-L-alanyl-L-isoleucyl-L-threonyl-L-valyl-L-leucyl-L-valyl-L-lysine, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C40H75N9O10 • XCF3COOH

Formula Weight: 842,1

Shelf life (days): 1460

Notes: CALP1 is an 8-residue calcium-like peptide that interacts with an EF hand motif based on the troponin C superfamily calcium binding site.{39607} It binds to calmodulin (Kd = 88 µM) and activates phosphodiesterase in the presence of calmodulin and absence of calcium. CALP1 also acts as a cell-permeable inhibitor of calcium influx through glutamate receptor channels in cultured rat neocortical neurons thereby inhibiting excitatory cytotoxicity (IC50 = 52.48 µM) and apoptosis (IC50 = 44.78 µM).{39608} CALP1 (1 mg/kg) pretreatment prevents increases in lung alveolar inflammatory cells after six, but not 24, hours in sensitized guinea pigs challenged with ovalbumin in a model of allergic asthma.{39609} It also decreases radical production induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in broncho-alveolar lavage cells after six and 24 hours and dose-dependently decreases histamine-induced hyperresponsiveness in isolated guinea pig tracheal rings.

• Artikelnummer: CAY24402-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24402-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK