Camostat-d6 (hydrochloride), CAS 2930627-60-2

Formulation: A solid

Formal Name: 4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-benzeneacetic acid, 2-(di(methyl-d3)amino)-2-oxoethyl ester, monohydrochloride

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C20H16D6N4O5 • HCl

Formula Weight: 440,9

Shelf life (days): 1460

CAS Number: 2930627-60-2

Notes: Camostat-d6 is intended for use as an internal standard for the quantification of camostat (Item No. 16018) by GC- or LC-MS. Camostat (50 µM) inhibits entry of vesicular stomatitis virus (VSV) particles pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 spike glycoprotein in Calu-3 cells and primary human lung epithelial cells.{49542} It reduces the number of SARS-CoV-2 genomic equivalents, a marker of infection, in Calu-3 cells. Camostat inhibits sodium channel function in human airway epithelial cells (IC50 = 50 nM) and enhances mucociliary clearance in sheep.{26503} Dietary administration of camostat (1 mg/kg) inhibits the production of TNF-α and chemokine (C-C motif) ligand 2 (CCL2) by monocytes, as well as proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis.{26054}

• Artikelnummer: CAY30984-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30984-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung