Candesartan, CAS 139481-59-7

Formulation: A solid

Formal Name: 2-ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid

Purity: ≥95%

Formula Markup: C24H20N6O3

Formula Weight: 440,5

Shelf life (days): 1460

CAS Number: 139481-59-7

Notes: Candesartan is an antagonist of the angiotensin II type 1 (AT1) receptor (Kis = 0.17, 0.12, and 0.12 nM for recombinant human AT1, rat AT1A, and rat AT1B receptors, respectively) and an active metabolite of the prodrug candesartan cilexitil (Item No. 10489).{28032} It is selective for AT1 over AT2 receptors (Ki = 26,500 nM for the recombinant human AT2 receptor). It inhibits angiotensin II-induced contraction of isolated rabbit aortic strips and increases in blood pressure in rats following intravenous administration (ID50 = 0.033 mg/kg).{42295} Formulations containing candesartan have been used in the treatment of hypertension and heart failure.

• Artikelnummer: CAY9003239-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9003239-1
• Green Labware: Nein
• Verpackungseinheit: 1 g
• Mengeneinheit: STK