Capromorelin (tartrate), CAS 193273-69-7

Formulation: A crystalline solid

Formal Name: 2-amino-N-[(1R)-2-[(3aR)-2,3,3a,4,6,7-hexahydro-2-methyl-3-oxo-3a-(phenylmethyl)-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methyl-propanamide, (2R,3R)-2,3-dihydroxybutanedioate

Purity: ≥98%

Formula Markup: C28H35N5O4 • C4H6O6

Formula Weight: 655,7

Shelf life (days): 1460

CAS Number: 193273-69-7

Notes: Capromorelin is a growth hormone (GH) secretagogue and an agonist of GH secretagogue receptor 1a (GHS-R1a), which is also known as the ghrelin receptor.{60360,60361} It stimulates GH release from primary rat pituitary cells with an EC50 value of 3 nM.{60360} Capromorelin (0.3, 3, and 30 nM) stimulates intracellular calcium mobilization in primary rat pituitary cells. It increases rat serum GH levels (ED50 = 0.04 mg/kg, i.v.) and decreases dog serum insulin-like growth factor 1 (IGF-1) levels when administered orally at a dose of 1 mg/kg. Capromorelin (3.9 mg/kg, once per day for 28 days) increases rat body weight by 43.6% without affecting whole-body percentages of fat, lean mass, or bone content. It decreases infarct size in a rabbit model of ischemia-reperfusion injury induced by left coronary artery occlusion when administered at a dose of 25 mg/kg.{60362} Formulations containing capromorelin have been used in the treatment of weight loss in cats with chronic kidney disease and as an appetite stimulant in dogs.

• Artikelnummer: CAY33488-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33488-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK