Capsiate, CAS 205687-01-0

Formulation: A liquid

Formal Name: 8-methyl-6E-nonenoic acid, (4-hydroxy-3-methoxyphenyl)methyl ester

Purity: ≥85% (mixture of isomers)

Formula Markup: C18H26O4

Formula Weight: 306,4

Shelf life (days): 730

CAS Number: 205687-01-0

Notes: Capsiate is a non-pungent analog of capsaicin (Item Nos. 92350 / 10010743) that has been found in C. annuum and has diverse biological activities.{61412,61415,61416,61417} It inhibits Src in, as well as VEGF-induced proliferation of and tube formation by, human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 25 µM.{61412} Capsiate activates transient receptor potential vanilloid 1 (TRPV1) in HEK293 cells expressing the human channel (EC50 = 290 nM) and induces licking and biting behaviors, markers of nociception, in mice.{61415} Topical application of capsiate reduces antigen-induced increases in ear thickness in a mouse model of passive cutaneous anaphylaxis and decreases epidermal thickness and eosinophil and mast cell infiltration in a mouse model of atopic dermatitis.{61416} Capsiate (10 mg/kg) decreases body weight gain and perirenal fat weight, as well as increases oxygen consumption, fat oxidation, and carbohydrate oxidation, in a mouse model of ad libitum feeding-induced weight gain.{61417}

• Artikelnummer: CAY9002596-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9002596-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK