Carbetocin (acetate), CAS 1631754-28-3

Formulation: A crystalline solid

Formal Name: N-(4-mercapto-1-oxobutyl)-O-methyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucyl-glycinamide, cyclic (1→5)-thioether, acetate

Purity: ≥98%

Formula Markup: C45H69N11O12S • XC2H4O2

Formula Weight: 988,2

Shelf life (days): 1460

CAS Number: 1631754-28-3

Notes: Carbetocin is an oxytocin receptor agonist and a peptide analog of oxytocin (Item No. 11799).{62008} It selectively binds to oxytocin receptors over vasopressin V2 receptors (Kds = 1.96 and 61.3 nM, respectively). Carbetocin induces contraction of isolated rat uterine strips (EC50 = 48 nM) and inhibits oxytocin-induced contraction of isolated rat uterine strips (pA2 = 8.21). In vivo, carbetocin (0.35 mg/animal) increases the frequency and amplitude of uterine contractions in early postpartum dairy cows.{62009} Carbetocin (6.4 mg/kg, i.p.) prevents stress-induced reinstatement of morphine-seeking behavior in mice.{62010} It also reverses learned helplessness and decreases social withdrawal induced by chronic unpredictable stress in tree shrews.{62011} Formulations containing carbetocin have been used in the prevention of excessive bleeding after childbirth.

• Artikelnummer: CAY33234-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33234-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK