Carboxyamidotriazole, CAS 99519-84-3

Formulation: A solid

Formal Name: 5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide

Purity: ≥98%

Formula Markup: C17H12Cl3N5O2

Formula Weight: 424,7

Shelf life (days): 1460

CAS Number: 99519-84-3

Notes: Carboxyamidotriazole is an orally bioavailable, non-selective calcium channel blocker.{45500} It blocks L- and T-type calcium channels in GH3 rat pituitary cancer cells (IC50s = 0.5 and 1.5 μg/ml, respectively). It also inhibits calcium influx stimulated by the acetylcholine receptor agonist carbachol (carbamoylcholine; Item No. 14486) and the calcium ionophore A23187 (Item Nos. 11016 / 22030) in CHO cells expressing human recombinant muscarinic M5 receptors (IC50s = 935 and 359 nM, respectively).{45501} Carboxyamidotriazole inhibits the growth of T. gondii in non-cancerous human fibroblasts and HeLa human cervical cancer cells (IC50 = 0.06 μg/ml for both).{45502} It inhibits the growth of FaDu and EVSCC17M human squamous cell carcinoma cells (IC50s = 13 and 15 μM, respectively) and of human umbilical vein endothelial cells (HUVECs; IC50 = 1 μM) in vitro.{45503,45504} Carboxyamidotriazole (20 μM) also inhibits angiogenesis in a chicken chorioallantoic membrane assay in vivo.{45504}

• Artikelnummer: CAY28732-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28732-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK