Carebastine-d5, CAS 1189661-02-6

Formulation: A solid

Formal Name: 4-[4-[4-(phenyl-d5)-phenylmethoxy)-1-piperidinyl]-1-oxobutyl]-α,α-dimethyl benzeneacetic acid

Purity: ≥99% deuterated forms (d1-d5)

Formula Markup: C32H32D5NO4

Formula Weight: 504,7

Shelf life (days): 1460

CAS Number: 1189661-02-6

Notes: Carebastine-d5 is intended for use as an internal standard for the quantification of carebastine (Item No. 23076) by GC- or LC-MS. Carebastine is an active metabolite of ebastine (Item No. 15372) and a histamine H1 receptor antagonist (Ki = 75.86 nM).{24985,34756,64270} It inhibits histamine-induced contraction of isolated guinea pig trachea (IC50 = 120 nM).{64271} It also inhibits histamine release from isolated rat peritoneal mast cells and human basophils when used at concentrations ranging from 30 to 100 µM. Carebastine decreases production of chemokine (C-C motif) ligand 5 (CCL5) and CCL2 in human nasal epithelial cells isolated from patients with nasal allergies.{41052}

• Artikelnummer: CAY30755
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30755-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung