Carisbamate, CAS 194085-75-1

Formulation: A solid

Formal Name: (1S)-1-(2-chlorophenyl)-1,2-ethanediol, 2-carbamate

Purity: ≥98%

Formula Markup: C9H10ClNO3

Formula Weight: 215,6

Shelf life (days): 1460

CAS Number: 194085-75-1

Notes: Carisbamate is an antiepileptic agent.{37173},{37174} In vivo, administration of carisbamate (10-60 mg/kg) dose-dependently reduces spike and wave discharges in the frontoparietal cortex in a rat model of absence seizures.{37173} Carisbamate (10 mg/kg) increases latency to the first running episode in the Wistar audiogenic sensitive rat model of convulsive seizures. It also reduces motor seizure frequency in a rat model of spontaneous seizures in a dose-dependent manner.{37174} Carisbamate blocks Nav1.2 channels (IC50 = 68 μM for rat channels) and inhibits repetitive firing of action potentials in rat hippocampal neurons in a dose-dependent manner.{37175} It also reduces T-type Ca2+ currents in HEK cells transfected with human recombinant Cav3.1 channels at a concentration of 300 μM.{37176}

• Artikelnummer: CAY23514-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23514-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK