CCMI, CAS 917837-54-8

Formulation: A solid

Formal Name: N-(4-chlorophenyl)-α-[[(4-chlorophenyl)amino]methylene]-3-methyl-5-isoxazoleacetamide

Purity: ≥95%

Formula Markup: C19H15Cl2N3O2

Formula Weight: 388,3

Shelf life (days): 1460

CAS Number: 917837-54-8

Notes: CCMI is a positive allosteric modulator (PAM) of α7 nicotinic acetylcholine receptors (nAChRs).{51518} It enhances ACh-, nicotine-, or choline-induced currents in Xenopus oocytes expressing recombinant human α7 nAChRs (EC50s = 0.7, 0.6, and 0.5 µM, respectively). In vivo, CCMI (0.3 and 1 mg/kg, i.v.) improves sensory gating deficits in a paired auditory stimulus paradigm in mice. It decreases the latency to find the platform in the Morris water maze test in a rat model of traumatic brain injury (TBI) induced by parasagittal fluid-percussion.{51519}

• Artikelnummer: CAY37571-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37571-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK