CD437, CAS 125316-60-1

Formulation: A crystalline solid

Formal Name: 6-(4-hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid

Purity: ≥95%

Formula Markup: C27H26O3

Formula Weight: 398,5

Shelf life (days): 1460

CAS Number: 125316-60-1

Notes: CD437 is the prototypical adamantyl arotinoid of the retinoid-related molecule family that acts as a selective agonist of retinoic acid receptor (RAR)γ (Kds = 6.5 μM, 2.5 μM, and 77 nM for RARα, β, and γ, respectively).{24739,24736} CD437 is cytotoxic to the acute myeloid leukemia cell line NB4 (EC50 = 0.17 μM), inducing DNA damage by producing DNA double strand breaks.{24735} CD437 also induces cell cycle arrest and apoptosis in various other cancer cells including melanoma, breast, non-small lung, and prostate cancer cells through RAR-dependent and -independent signaling pathways.{24737,24738}

• Artikelnummer: CAY71610-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 71610-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK