Cetrorelix (acetate), CAS 145672-81-7

Formulation: A solid

Formal Name: N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide, acetate

Purity: ≥95%

Formula Markup: C70H92ClN17O14 • XC2H4O2

Formula Weight: 1431,1

Shelf life (days): 1460

CAS Number: 145672-81-7

Notes: Cetrorelix is a synthetic peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with a Kd value of 0.2 nM for radioligand binding to murine LTK- cells expressing human GnRHR.{42016} It inhibits the activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells by the GnRHR agonist [D-Trp6]GnRH (IC50 = 1.2 nM). In vivo, cetrorelix (60 μg per day) reduces tumor volume to 35% of control and decreases serum luteinizing hormone levels by 50% in a human epithelial ovarian cancer mouse xenograft model.{42017} Centrorelix (0.5 mg/kg) protects the primordial follicles (PMF) in mouse ovaries from damage induced by cyclophosphamide (Item No. 13849) with 65% to 86% PMF survival compared to 46% PMF survival with a saline control.{42018} Formulations containing cetrorelix have been used to prevent ovulation during in vitro fertilization.

• Artikelnummer: CAY23910-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23910-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK