CGRP (8-37) (mouse, rat) (trifluoroacetate salt)

Formulation: A solid

Formal Name: (S)-4-((S)-2-(2-((S)-2-((S)-2-((2S,3R)-2-((S)-1-(L-valyl-L-threonyl-L-histidyl-L-arginyl-L-leucyl-L-alanylglycyl-L-leucyl-L-leucyl-L-seryl-L-arginyl-L-serylglycylglycyl-L-valyl-L-valyl-L-lysyl-L-aspartyl-L-asparaginyl-L-phenylalanyl-L-valyl)pyrrolidine-2-carboxamido)-3-hydroxybutanamido)-4-amino-4-oxobutanamido)-3-methylbutanamido)acetamido)-3-hydroxypropanamido)-5-(((S)-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C138H224N42O41 • XCF3COOH

Formula Weight: 3127,5

Shelf life (days): 1460

Notes: Calcitonin gene-related protein (CGRP) (8-37) is a CGRP receptor antagonist.{41531} It corresponds to amino acids 8-37 of rodent α-CGRP (Item No. 24728), a neuropeptide. CGRP (8-37) selectively binds to heterotrimeric complexes of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1) or RAMP3 (IC50s = 1 and 6.2 nM, respectively) over a complex of CRLR and RAMP2 (IC50 = 219 nM). It prevents CGRP-induced increases in heart rate and decreases in blood pressure in transgenic mice expressing rat CRLR in smooth muscle-containing tissues and sympathetic ganglia when administered at a dose of 2 µmol/kg.{69074} CGRP (8-37) also inhibits p-phenylquinone-induced writhing (ED50 = 6 µg/animal) and decreases body temperature in a dose-dependent manner in mice.{69075}

• Artikelnummer: CAY35645-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35645-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: Reinstoffe