CGS 15943, CAS 104615-18-1

Formulation: A crystalline solid

Formal Name: 9-chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

Purity: ≥95%

Formula Markup: C13H8ClN5O

Formula Weight: 285,7

Shelf life (days): 1460

CAS Number: 104615-18-1

Notes: CGS 15943 is an orally bioavailable non-xanthine antagonist at adenosine (A) receptors with IC50 values of 3.5, 4.2, 16, and 51 nM in CHO cells transfected with human recombinant A1, A2A, A2B, and A3 receptors, respectively.{34118,39224} It also binds to the phosphatidylinositol 3-kinase (PI3K) catalytic subunit p110γ, and it inhibits proliferation of HCC hepatocellular carcinoma and PDAC pancreatic cancer adenocarcinoma cells through the PI3K/Akt signaling pathway.{39223} In rats, CGS 15943 (0.1-10 mg/kg, i.p.) increases locomotor activity in a dose-dependent manner.{39225} It also reinforces and reinstates cocaine-seeking in baboons through an adenosine-dependent mechanism.{39226}

• Artikelnummer: CAY22073-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22073-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK