Chlorpheniramine-d6 (maleate), CAS 1219806-45-7

Formulation: A solid

Formal Name: 3-(4-chlorophenyl)-N,N-bis(methyl-d3)-3-(pyridin-2-yl)propan-1-amine maleate

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C16H13ClD6N2 • C4H4O4

Formula Weight: 396,9

Shelf life (days): 1460

CAS Number: 1219806-45-7

Notes: Chlorpheniramine-d6 is intended for use as an internal standard for the quantification of chlorpheniramine (Item No. 21253) by GC- or LC-MS. Chlorpheniramine is a histamine H1 receptor antagonist with an IC75 value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum.{39804} It protects against intravenous histamine-induced death (PD50 = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED100sec = 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits.{39805} It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma.{39806} Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.

• Artikelnummer: CAY35767-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35767-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung