CIM0216, CAS 1031496-06-6

Formulation: A solid

Formal Name: 3,4-dihydro-N-(5-methyl-3-isoxazolyl)-α-phenyl-1(2H)-quinolineacetamide

Purity: ≥95%

Formula Markup: C21H21N3O2

Formula Weight: 347,4

Shelf life (days): 1460

CAS Number: 1031496-06-6

Notes: CIM0216 is a transient receptor potential melastatin 3 (TRPM3) activator. It induces inward and outward rectifying currents in TRPM3-expressing HEK293 cells voltage-clamped at ±80 mV when used at a concentration of 1 µM.{48910} CIM0216 is selective for TRMP3 over TRPM1, TRPM4, TRPM6, and TRMP7 in HEK293 cells expressing the human channels, but does activate TRPA1 by 15% in CHO cells expressing mouse TRPA1 at 10 µM. CIM0216 also inhibits ADP-ribose-induced TRPM2, calcium-induced TRMP5, and methanol-induced TRPM8 activation by 17, 34, and 61%, respectively, in HEK293 cells expressing the human channels at 10 µM. It stimulates insulin and calcitonin gene-related peptide (CGRP) release in isolated mouse pancreatic islets and skin nerve terminals, respectively, when used at concentrations ranging from 5 to 100 µM.{48910} CIM0216 (20 µM) induces activation of the TRPM3 signal transduction transcription factor AP-1 and its subunits, c-Jun and c-fos, in HEK293 cell reporter assays.{48911}

• Artikelnummer: CAY27684-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27684-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK