Cinacalcet-d3 (hydrochloride), CAS 2749807-20-1

Formulation: A solid

Formal Name: (αR)-α-(methyl-d3)-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine, monohydrochloride

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C22H19D3F3N • HCl

Formula Weight: 396,9

Shelf life (days): 1460

CAS Number: 2749807-20-1

Notes: Cinacalcet-d3 is intended for use as an internal standard for the quantification of cinacalcet (Item No. 16042) by GC- or LC-MS. Cinacalcet is a calcimimetic and an allosteric agonist of the calcium-sensing receptor (CaSR; EC50 = 79.4 nM in HEK293T cells expressing the human receptor).{26279} In vivo, cinacalcet (0.1-10 mg/kg, s.c.) decreases plasma levels of parathyroid hormone (PTH) in rats. It also decreases plasma levels of PTH and parathyroid cell proliferation in a mouse model of primary hyperparathyroidism.{39827} Formulations containing cinacalcet have been used in the treatment of secondary hyperparathyroidism due to end-stage renal disease and hypercalcemia in patients with parathyroid carcinoma.

• Artikelnummer: CAY25036-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25036-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung