Cinnarizine-d8, CAS 1185242-27-6

Formulation: A solid

Formal Name: 1-(diphenylmethyl)-4-(3-phenyl-2-propen-1-yl)-piperazine-2,2,3,3,5,5,6,6-d8

Purity: ≥99% deuterated forms (d1-d8)

Formula Markup: C26H20D8N2

Formula Weight: 376,6

Shelf life (days): 1460

CAS Number: 1185242-27-6

Notes: Cinnarizine-d8 is intended for use as an internal standard for the quantification of cinnarizine (Item No. 21001) by GC- or LC-MS. Cinnarizine is a calcium channel inhibitor and histamine H4 receptor antagonist (Ki = 142 nM).{54940,54941,32995} It inhibits L- and T-type calcium channels in isolated guinea pig atrial cells in a voltage-dependent manner.{54940} Cinnarizine inhibits L-type calcium currents in isolated guinea pig type II vestibular hair cells (IC50 = 1.5 µM). In vivo, cinnarizine (10 mg/kg) inhibits ethanol-induced gastric ulcer formation in rats.{54942} Formulations containing cinnarizine have been used in the treatment of nausea and vomiting due to vertigo, Meniere's disease, or chemotherapy.

• Artikelnummer: CAY33977-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33977-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung