CINPA1, CAS 102636-74-8

Formulation: A crystalline solid

Formal Name: [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]-carbamic acid, ethyl ester

Purity: ≥98%

Formula Markup: C23H29N3O3

Formula Weight: 395,5

Shelf life (days): 1460

CAS Number: 102636-74-8

Notes: CINPA1 is a constitutive androstane receptor (CAR) antagonist (IC50 = 70 nM in a reporter assay).{48670} It is selective for CAR over the nuclear receptors GR, FXR, LXRα, LXRβ, PPARγ, RXRα, and RXRβ at 18 μM, but also antagonizes the human pregnane X receptor (PXR; IC50 = 6.6 μM). CINPA1 (0.3-5 μM) inhibits CAR transactivation of CYP2B6 induced by CITCO (Item No. 16027) in primary human hepatocytes.

• Artikelnummer: CAY29110-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29110-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK