Cirazoline (hydrochloride), CAS 40600-13-3

Formulation: A crystalline solid

Formal Name: 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole, monohydrochloride

Purity: ≥98%

Formula Markup: C13H16N2O • HCl

Formula Weight: 252,7

Shelf life (days): 1460

CAS Number: 40600-13-3

Notes: Cirazoline is an α1-adrenergic receptor (α1-AR) agonist (Kis = 120, 960, and 660 nM for recombinant α1A-, α1B-, and α1D-ARs, respectively, in CHO cell membranes).{41231} It acts as a full agonist at α1A- and a partial agonist at α1B- and α1D-ARs in vitro (EC50s = 70.7, 79.4, and 239.8 nM, respectively). It also acts as an antagonist at α2-ARs with a pA2 value of 7.56 to inhibit the norepinephrine-induced twitch response in isolated pig ileum.{41105} Cirazoline (0.01-1 µg/kg) decreases blood pressure when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats.{36359} It enhances spatial memory and reduces depressive- and anxiety-like behavior in mice when administered at a concentration of 10 mg/L in drinking water for 2-9 months.{35157} It also enhances performance in the variable delayed response task in aged rhesus monkeys at high doses of 1-10 µg/kg but impairs performance at lower doses of 0.01-1 µg/kg.{35155}

• Artikelnummer: CAY21791-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21791-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK