Cisapride-d6

Formulation: A solid

Formal Name: rel-4-amino-5-chloro-N-[1-[(3R,4S)-3-(4-fluorophenoxy)propyl-d6]-3-methoxy-4-piperidinyl]-2-methoxy-benzamide

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C23H23D6ClFN3O4

Formula Weight: 472

Shelf life (days): 1460

Notes: Cisapride-d6 is intended for use as an internal standard for the quantification of cisapride (Item No. 21657) by GC- or LC-MS. Cisapride is an agonist of serotonin (5-HT) receptor subtype 5-HT4 (IC50 = 0.483 μM in COS-7 cells expressing the human receptor).{34540} It induces relaxation of precontracted isolated rat esophageal thoracic muscularis mucosae preparations (EC50 = 102.33 nM). Cisapride (0.5 mg/kg) increases the rate of gastric emptying in rats. It is also a human ether-a-go-go related gene (hERG) channel blocker that binds to hERG channels with an IC50 value of less than 1 μM in a fluorescence polarization assay. Formulations containing cisapride have previously been used in the treatment of nocturnal heartburn associated with gastroesophageal reflux disease.

• Artikelnummer: CAY28701-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28701-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung