Clozapine N-oxide (hydrochloride), CAS 2250025-93-3

Formulation: A crystalline solid

Formal Name: 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine, dihydrochloride

Purity: ≥98%

Formula Markup: C18H19ClN4O • 2HCl

Formula Weight: 415,7

Shelf life (days): 730

CAS Number: 2250025-93-3

Notes: Clozapine N-oxide is a major metabolite of clozapine (Item No. 12059) and an activator of designer receptors exclusively activated by designer drugs (DREADDs) derived from human muscarinic acetylcholine receptors (EC50s = 16.7, 323, 17.4, 18.3, and 18.7 nM for PASMCs expressing hM1-5D receptors, respectively).{27576,35354} It prevents action potential firing in cultured hippocampal neurons transiently expressing hM4D receptors.{35354} Clozapine N-oxide increases glutamate in the nucleus accumbens core and inhibits cue-induced reinstatement of cocaine-seeking behavior in rats transfected with hM3Dq DREADD receptors.{42492}

• Artikelnummer: CAY25780-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25780-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK