COG133 (trifluoroacetate salt), CAS 514200-66-9

Formulation: A solid

Formal Name: N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-leucinamide, trifuoroacetate salt

Purity: ≥95%

Formula Markup: C97H181N37O19 • XCF3COOH

Formula Weight: 2169,7

Shelf life (days): 1460

CAS Number: 514200-66-9

Notes: COG133 is a peptide fragment of ApoE that corresponds to residues 133-149 of the ApoE LDL receptor-binding domain and an antagonist of α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 720 nM).{61382,61383} It suppresses TNF-α and nitric oxide (NO) release in BV-2 microglia when used at concentrations ranging from 10 to 50 µM.{61382} In vivo, COG133 reduces LPS-induced increases in brain levels of TNF-α and IL-6 in mice.{61384} It decreases hippocampal neuronal degeneration and the latency to find the platform in the Morris water maze in a mouse model of closed head injury induced by surgical midline impact when administered at doses of 203 and 406 µg/kg.{61385} COG133 (1 mg/kg) also delays disease onset and reduces disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).{61386}

• Artikelnummer: CAY33587-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33587-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK