Conivaptan-d4, CAS 1129433-63-1

Formulation: A solid

Formal Name: N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl-d4]-[1,1'-biphenyl]-2-carboxamide

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C32H22D4N4O2

Formula Weight: 502,6

Shelf life (days): 1460

CAS Number: 1129433-63-1

Notes: Conivaptan-d4 is intended for use as an internal standard for the quantification of conivaptan (Item No. 23728) by GC- or LC-MS. Conivaptan is an antagonist of the arginine vasopressin (AVP) receptors V1A and V2 (Kis = 0.48 and 3.04 nM for rat liver V1A and kidney V2, respectively).{38430} It also competitively inhibits oxytocin binding to rat uterine oxytocin receptors (Ki = 44 nM) but has no effect on AVP binding to anterior pituitary V1B receptors at concentrations up to 100 μM in a radioligand binding assay. Conivaptan suppresses AVP-induced increases in intracellular calcium in vascular smooth muscle cells (VSMCs) in vitro and the pressor response in pithed rats. Conivaptan (0.01-0.3 mg/kg, i.v.) increases urine output and decreases urine osmolality in dehydrated conscious rats in a dose-dependent manner. It also reduces brain edema and blood-brain barrier disruption in a mouse experimental stroke model.{38431}

• Artikelnummer: CAY26455-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26455-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung