CpdA, CAS 14593-25-0

Formulation: A crystalline solid

Formal Name: 4-[1-chloro-2-(methylamino)ethyl]-phenol 1-acetate, monohydrochloride

Purity: ≥98%

Formula Markup: C11H14ClNO2 • HCl

Formula Weight: 264,1

Shelf life (days): 1460

CAS Number: 14593-25-0

Notes: CpdA is a non-steroidal selective glucocorticoid receptor modulator.{33998} It is an aziridine precursor that can infiltrate cells and is translocated to the nucleus.{33998,33996} It inhibits glucocorticoid receptor dimerization, which prevents transcription of gene targets such as NF-κB and subsequent cytokines through transrepression.{33997} Studies have shown contradictory results for binding affinity of CpdA compared with dexamethasone (Item No. 11015) that were either higher (4-fold, IC50 = 6.4 nM and 25.9 nM, respectively, in L929sA cells) or lower (63-fold, Kd = 81.8 nM and 1.29 nM, respectively, in BWTG3 cells) in whole cell binding assays.{33996,33997}

• Artikelnummer: CAY21438-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21438-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK