CU-CPT8m, CAS 125079-83-6

Formulation: A crystalline solid

Formal Name: 7-(3-methylphenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxamide

Purity: ≥98%

Formula Markup: C14H12N4O

Formula Weight: 252,3

Shelf life (days): 1460

CAS Number: 125079-83-6

Notes: CU-CPT8m is an antagonist of toll-like receptor 8 (TLR8; Kd = 220 nM; IC50 = 67 nM in a reporter assay).{35162} It is selective for TLR8 over a panel of all other human TLRs when used at a concentration of 1 μM. CU-CPT8m (1 μM) inhibits increases in TNF-α and IL-8 mRNA expression induced by the TLR8 agonist R-848 (Item No. 14806) in TLR8-overexpressing HEK-Blue cells. It also inhibits R-848-induced increases in TNF-α protein levels in differentiated THP-1 monocytes and human primary peripheral blood mononuclear cells (PBMCs) in a concentration-dependent manner. CU-CPT8m decreases TNF-α and IL-8 levels in synovial cells derived from patients with osteoarthritis and TNF-α levels in PBMCs derived from patients with rheumatoid arthritis.

• Artikelnummer: CAY25349-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25349-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK