CVT-6883, CAS 752222-83-6

Formulation: A solid

Formal Name: 3-ethyl-3,9-dihydro-1-propyl-8-[1-[[3-(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-1H-purine-2,6-dione

Purity: ≥98%

Formula Markup: C21H21F3N6O2

Formula Weight: 446,4

Shelf life (days): 1460

CAS Number: 752222-83-6

Notes: CVT-6883 is an adenosine A2B receptor antagonist (Ki = 22 nM).{57672} It is selective for adenosine A2B over adenosine A1, A2A, and A3 receptors (Kis = 1,940, 3,280, and 1,070 nM, respectively), as well as a panel of 84 receptors, ion channels, transporters, and enzymes at 10 µM. CVT-6883 (6 mg/kg) decreases allergen challenge-induced bronchoalveolar lavage fluid (BALF) eosinophil and lymphocyte infiltration and airway reactivity in a mouse model of allergic asthma.{57673} It also decreases fibrosis in the non-infarct zone, improves ejection fractions, and reduces ventricular tachycardia in a rat model of myocardial infarction.{57674}

• Artikelnummer: CAY33333-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33333-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK