CXCR3 Antagonist 6c, CAS 870998-13-3

Formulation: A crystalline solid

Formal Name: 4-[2-[(3-chlorobenzoyl)amino]-4-[[[2-(2,4-dichlorophenyl)ethyl]amino]carbonyl]phenyl]-N-ethylhexahydro-1H-1,4-diazepine-1-carboxamide

Purity: ≥98%

Formula Markup: C30H32Cl3N5O3

Formula Weight: 617

Shelf life (days): 1460

CAS Number: 870998-13-3

Notes: CXCR3 antagonist 6c is an antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3).{52334} It inhibits calcium mobilization induced by chemokine (C-X-C motif) ligand 11 (CXCL11) in HEK293 cells expressing the human receptor (IC50 = 0.06 µM). It is selective for CXCR3 over a panel of 14 human G protein-coupled receptors at 10 µM. CXCR3 antagonist 6c inhibits CXCR3-mediated migration of isolated human T cells (IC50 = ~100 nM).

• Artikelnummer: CAY29731-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29731-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK