Cyclizine (hydrochloride), CAS 303-25-3

Formulation: A solid

Formal Name: 1-(diphenylmethyl)-4-methyl-piperazine, monohydrochloride

Purity: ≥98%

Formula Markup: C18H22N2 • HCl

Formula Weight: 302,8

Shelf life (days): 1460

CAS Number: 303-25-3

Notes: Cyclizine is a histamine H1 receptor antagonist.{52784,52785,46616} It binds selectively to histamine H1 receptors (Kd = 5 nM) over H2 and H3 receptors (Kds = 1,600 and >580 nM, respectively).{46616} Cyclizine inhibits anti-IgE-induced histamine release from isolated human lung fragments with an IC50 value of 5.42 µM but induces histamine release with a 50% release concentration (RC50) of 10.81 µM.{52786} It reduces LPS-induced nitrite accumulation and protein levels of induced nitric oxide synthase (iNOS) in RAW 264.7 cells when used at a concentration of 100 nM.{52785} Cyclizine (10 and 20 mg/kg) reduces immobility in the forced swim test in rats.{52787}

• Artikelnummer: CAY31190-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31190-500
• Green Labware: Nein
• Verpackungseinheit: 500 mg
• Mengeneinheit: STK