D-Cycloserine, CAS 68-41-7

Formulation: A crystalline solid

Formal Name: 4R-amino-3-isoxazolidinone

Purity: ≥95%

Formula Markup: C3H6N2O2

Formula Weight: 102,1

Shelf life (days): 1460

CAS Number: 68-41-7

Notes: D-Cycloserine is an NMDA receptor (NMDAR) partial agonist with antibiotic activity. It selectively binds to the glycine binding site (Ki = 2.33 μM) over the glutamate binding site (Ki = >100 μM).{39065} D-Cycloserine modulates memory in a T-maze footshock test in CD-1 mice with optimal memory retention at doses of 10-30 mg/kg.{39066} Administration of D-cycloserine (20-40 mg/kg) improves memory retention in ‘senescence-accelerated’ mice which exhibit impaired learning and memory. D-Cycloserine inhibits L-alanine racemase and D-alanine:D-alanine ligase, enzymes essential to peptidoglycan synthesis and bacterial cell wall formation.{39068} Formulations containing D-cycloserine have been used as second-line agents to treat drug resistant tuberculosis.{39069}

• Artikelnummer: CAY22194-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22194-500
• Green Labware: Nein
• Verpackungseinheit: 500 mg
• Mengeneinheit: STK