D-erythro/L-threo Lysosphingomyelin (d18:1), CAS 82970-80-7

Formulation: A solid

Formal Name: 2-[[[(2-amino-3-hydroxy-4-octadecen-1-yl)oxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-ethanaminium, inner salt

Purity: ≥98%

Formula Markup: C23H49N2O5P

Formula Weight: 464,6

Shelf life (days): 1460

CAS Number: 82970-80-7

Notes: Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.{18803,18804} It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate (S1P; Item No. 62570). D-erythro Lysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3 (EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).{37413} It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (ORG1) that induces calcium accumulation in cells overexpressing OGR1 (EC50 = ~35 nM).{59108} Levels of D-erythro lysosphingomyelin are increased in skin isolated from patients with atopic dermatitis, as well as postmortem brain from patients with Niemann-Pick disease type A, but not type B.{18804,59109} L-threo lysosphingomyelin is also an S1P1-3 agonist (EC50s = 19.3, 131.8, and 313.3 nM, respectively).{37413} This product is a mixture of D-erythro and L-threo lysosphingomyelin. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1321]

• Artikelnummer: CAY31557-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31557-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK