Dapiprazole (hydrochloride), CAS 72822-13-0

Formulation: A crystalline solid

Formal Name: 5,6,7,8-tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-1,2,4-triazolo[4,3-a]pyridine, monohydrochloride

Purity: ≥98%

Formula Markup: C19H27N5 • HCl

Formula Weight: 361,9

Shelf life (days): 1460

CAS Number: 72822-13-0

Notes: Dapiprazole is an α-adrenergic receptor (α-AR) antagonist.{48750} It inhibits norepinephrine-induced contractions in rat vas deferens, guinea pig spleen, and rat aorta, regions that express high levels of α1A-AR, α1B-AR, and α1D-ARs, respectively (pA2s = 7.93, 7.13, and 8.26, respectively). It also inhibits contractions induced by histamine, angiotensin II, pentagastrin (Item No. 28546), carbamoylcholine (carbachol; Item No. 14486), and serotonin (Item No. 14332) in guinea pig ileum in a dose-dependent manner.{48751} Dapiprazole (0.05%, intracameral) reverses pupil dilation induced by a combination of the α1A-AR agonist phenylephrine and the muscarinic M4 antagonist tropicamide (Item No. 16606) in rabbits.{48752} Formulations containing dapiprazole have been used in the treatment of iatrogenically induced mydriasis by adrenergic or parasympatholytic agents in certain eye examinations.

• Artikelnummer: CAY29222-250
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29222-250
• Green Labware: Nein
• Verpackungseinheit: 250 mg
• Mengeneinheit: STK