DCPIB, CAS 82749-70-0

Formulation: A crystalline solid

Formal Name: 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]-butanoic acid

Purity: ≥98%

Formula Markup: C22H28Cl2O4

Formula Weight: 427,4

Shelf life (days): 1460

CAS Number: 82749-70-0

Notes: DCPIB is an inhibitor of volume-regulated anion channels (VRAC).{57751} It inhibits the swelling-induced chloride current (ICl,swell) in bovine pulmonary artery endothelial cells (IC50 = 4.1 µM). DCPIB inhibits the VRAC subunit leucine-rich containing 8A (LRRC8A; IC50 = 20.9 µM) and inhibits sphingosine-1-phosphate-induced cGAMP uptake by LRRC8A in telomerase-immortalized human microvascular endothelial (TIME) cells when used at a concentration of 20 µM.{57753,57754} It also inhibits the two-pore domain potassium channels K2P18.1/TRESK, K2P3.1/TASK1, and K2P9.1/TASK3 in COS-7 cells expressing the human channels (IC50s = 0.14, 0.95, and 50.72 µM, respectively).{57752} DCPIB (10 µM) activates K2P2.1/TREK1 and K2P4.1/TRAAK channels in COS-7 cells expressing the human channels. Intracisternal administration of DCPIB (20 µg/kg) reduces infarct area and neurological deficit scores in a rat model of cerebral ischemia induced by middle cerebral artery occlusion (MCAO).{57755}

• Artikelnummer: CAY34064-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34064-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK