Decamethonium (bromide), CAS 541-22-0

Formulation: A crystalline solid

Formal Name: N1,N1,N1,N10,N10,N10-hexamethyl-1,10-decanediaminium, dibromide

Purity: ≥98%

Formula Markup: C16H38N2 • 2Br

Formula Weight: 418,3

Shelf life (days): 1460

CAS Number: 541-22-0

Notes: Decamethonium is a depolarizing neuromuscular blocking agent.{42107} It is a partial agonist of muscle-type nicotinic acetylcholine receptors (nAChRs).{42108} Decamethonium activates α1β1-containing adult mouse muscle-type nAChRs expressed in X. laevis oocytes with an EC50 value of 40 µM using voltage clamp electrophysiology. It is also a nondepolarizing antagonist of neuronal-type nAChRs, inhibiting mouse α7-, α3β2-, α3β4-, and α4β2-containing receptors with IC50 values of 7.4, 405, 28, and 59 µM, respectively. Decamethonoium is a competitive antagonist of α4β2-containing nAChRs expressed in SH-EP1 cells (IC50 = 52 µM for the human receptor).{27173} It also inhibits electric eel acetylcholinesterase (AChE) and blocks electrically-evoked tibialis muscle twitches in anesthetized cats with ED95 values of 35 and 70 µg/kg for cats under chloralose and ether anesthesia, respectively.{42107,19407} Formulations containing decamethonium have been used to induce paralysis during anesthesia.

• Artikelnummer: CAY24907-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24907-10
• Green Labware: Nein
• Verpackungseinheit: 10 g
• Mengeneinheit: STK