Dermorphin (acetate)

Formulation: A crystalline solid

Formal Name: (S)-1-(L-tyrosyl-D-alanyl-L-phenylalanylglycyl-L-tyrosyl)-N-((S)-1-amino-3-hydroxy-1-oxopropan-2-yl)pyrrolidine-2-carboxamide, acetate

Purity: ≥95%

Formula Markup: C40H50N8O10 • XC2H4O2

Formula Weight: 802,9

Shelf life (days): 1460

Notes: Dermorphin is an opioid peptide originally isolated from the skin of South American frogs (Ph. sauvagei).{60135} It binds to μ-opioid receptors (Ki = 0.54 nM) and is selective for μ- over δ-opioid receptors in radioligand binding assays (Ki = 929 nM). In vivo, dermorphin (1.9 µmol/kg, i.p.) inhibits noxious stimuli-induced neuronal firing in the nucleus lateralis anterior and ventrobasal complex in rats.{60136} It inhibits the electrical stimulation-induced C fiber response in rat dorsal horn nociceptive neurons. Dermorphin (10-120 pmol/animal, i.c.v.) delays gastric emptying, inhibits gastric acid secretion, and slows colonic motility in pylorus-ligated rats.

• Artikelnummer: CAY31607-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31607-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK