(Des-octanoyl)-Ghrelin (human) (trifluoroacetate salt)

Formulation: A lyophilized powder

Formal Name: glycyl-L-seryl-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-α-glutamyl-L-histidyl-L-glutaminyl-L-arginyl-L-valyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-α-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-L-arginine, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C141H235N47O41 • XCF3COOH

Formula Weight: 3244,7

Shelf life (days): 1460

Notes: Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).{7811,37391} Ghrelin requires an n-octanoyl modification at serine 3 for binding to the growth hormone (GH) secretagogue receptor (GHS-R).{40067} (Des-octanoyl)-ghrelin (human) is a form of ghrelin that is lacking the octanoyl group at serine 3. It is located in the mouse stomach and is expressed at a lower level than octanoyl ghrelin.{41730} (Des-octanoyl)-ghrelin activates GHS-R by only 41% when used at 10 µM (IC50 = >10,000 nM; EC50 = >10,000 nM for increasing calcium accumulation).{41729} It induces bone marrow adipogenesis in rat models of growth hormone deficiency.{41731} (Des-octanoyl)-ghrelin also inhibits cell proliferation in estrogen-dependent MCF-7 breast cancer cells (EC50 = 0.81 µM) but induces proliferation of a somatotroph pituitary tumor cell line, an effect that can be blocked by MAPK, PKC, and tyrosine kinase inhibitors.{41732,41733}

• Artikelnummer: CAY25010-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25010-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK