desbutyl Lumefantrine, CAS 355841-11-1

Formulation: A solid

Formal Name: (9Z)-α-[(butylamino)methyl]-2,7-dichloro-9-[(4-chlorophenyl)methylene]-9H-fluorene-4-methanol

Purity: ≥95%

Formula Markup: C26H24Cl3NO

Formula Weight: 472,8

Shelf life (days): 1460

CAS Number: 355841-11-1

Notes: desbutyl Lumefantrine is an active metabolite of the antimalarial agent lumefantrine (Item No. 20678).{61731,61732} It is formed from lumefantrine by the cytochrome P450 (CYP) isoform CYP3A4.{61733} desbutyl Lumefantrine is active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50s = 9 and 9.5 nM, respectively).{61731} It inhibits the human-ether-a-go-go (hERG) potassium channel, also known as Kv11.1, in HEK293 cells expressing the human channel (IC50 = 5.49 µM).{61732}

• Artikelnummer: CAY24935-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24935-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK