Desloratadine-d4, CAS 2713301-38-1

Formulation: A solid

Formal Name: 8-chloro-6,11-dihydro-11-(4-piperidinylidene-3,3,5,5-d4)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C19H15ClD4N2

Formula Weight: 314,9

Shelf life (days): 1460

CAS Number: 2713301-38-1

Notes: Desloratadine-d4 is intended for use as an internal standard for the quantification of desloratadine (Item No. 16931) by GC- or LC-MS. Desloratadine is a histamine H1 receptor antagonist (Ki = 0.97 nM) and an active metabolite of loratadine (Item No. 15625).{27482,64192} It is formed from loratadine primarily by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2D6, and CYP2C19.{64193} It also inhibits calcium flow in neurons and glia in vitro (IC50s = 9.177 and 0.3185 µM, respectively), an effect that can be blocked by knockdown of the 5-HT receptor subtype 5-HT2A.{64190} Desloratadine (10 mg/kg) reduces ovalbumin-induced sneezing, nose rubbing, eye watering, and congestion in ovalbumin-sensitized guinea pigs.{64191} It also increases the clearance of amyloid-β by microglia and reverses learning and memory deficits in the Morris water maze in the transgenic APP/PS1 mouse model of Alzheimer’s disease when administered at a dose of 20 mg/kg per day.{64190} Formulations containing desloratadine have been used in the treatment of seasonal and perennial allergic rhinitis and chronic idiopathic urticaria.

• Artikelnummer: CAY26776-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26776-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung