Dezocine, CAS 53648-55-8

Formulation: A solid

Formal Name: (5R,11S,13S)-amino-5,6,7,8,9,10,11,12-octahydro-5-methyl-5,11-methanobenzocyclodecen-3-ol

Purity: ≥95%

Formula Markup: C16H23NO

Formula Weight: 245,4

Shelf life (days): 1460

CAS Number: 53648-55-8

Notes: Dezocine is a partial agonist of the µ- and κ-opioid receptors.{58497} It is selective for µ- and κ-opioid receptors (Kis = 1.46 and 22.01 nM, respectively) over the δ-opioid receptor (Ki = 398.6 nM). Dezocine inhibits the norepinephrine transporter (NET) and serotonin transporter (SERT) with Ki values of 0.001 and 109 nM, respectively.{58498} It stimulates [35S]GTPγS binding to CHO membranes expressing the human µ- and κ-opioid receptors with Emax values of 45.8 and 33.6% compared to the µ- and κ-agonists DAMGO and U50,488 H, respectively, when used at a concentration of 10 µM.{58497} It has antinociceptive effects in mice in the acetic acid abdominal constriction test (ED50 = 0.02 mg/kg) and the formalin test (ED50s = 0.4 mg/kg for both phases).{58497} Dezocine (10 mg/kg) increases the latency to tail withdrawal in the tail-flick test in rats.{58499} It also decreases the number of lung metastases in a 4T1 murine mammary cancer model when administered at doses ranging from 0.75 to 2 mg/kg.{58500} Formulations containing dezocine have been used in the treatment of post-operative pain.

• Artikelnummer: CAY34093
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34093-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK