Digoxin, CAS 20830-75-5

Formulation: A crystalline solid

Formal Name: (3β,5β,12β)-3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-card-20(22)-enolide

Purity: ≥98%

Formula Markup: C41H64O14

Formula Weight: 780,9

Shelf life (days): 1460

CAS Number: 20830-75-5

Notes: Digoxin is a cardiac glycoside and metabolite of digitoxin that binds to and inhibits the Na+/K+-ATPase in cardiac tissues in an ATP- and Mg2+-dependent manner.{38192} This inhibition results in loss of the transmembrane Na+ gradient, which decreases activity of the Na+/Ca2+ exchanger, increasing intracellular Ca2+ levels, inotropy, and cardiac force.{38193} It increases activity of mitochondrial ATPase and actomyosin ATPase in rat hearts, which is directly correlated with increased myofibrillar contractile strength.{38194} In vivo, digoxin also decreases right atrial pressure and increases cardiac output in a canine model of congestive heart failure produced by pulmonary artery constriction.{38195} Formulations containing digoxin have been used to treat atrial fibrillation.{38196}

• Artikelnummer: CAY22266-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22266-5
• Green Labware: Nein
• Verpackungseinheit: 5 g
• Mengeneinheit: STK