Diphenidol-d10, CAS 2928181-97-7

Formulation: A solid

Formal Name: α,α-diphenyl-1-piperidine-2,2,3,3,4,4,5,5,6,6-d10-butanol

Purity: ≥99% deuterated forms (d1-d10)

Formula Markup: C21H17D10NO

Formula Weight: 319,5

Shelf life (days): 1460

CAS Number: 2928181-97-7

Notes: Diphenidol-d10 is intended for use as an internal standard for the quantification of diphenidol (Item No. 18674) by GC- or LC-MS. Diphenidol is an antagonist of muscarinic acetylcholine receptors (mAChRs; Kis = 0.43, 2.8, 1.1, 0.91, and 1.28 µM in CHO cell membranes expressing M1-5 receptors, respectively).{61413} It also inhibits Kv channels in Neuro2A cells (IC50 = 28.2 µM), as well as L-type voltage-gated calcium channels in differentiated NG 108-15 cells in a concentration-dependent manner.{30250} Microiontophoretic application of diphenidol inhibits rotation-induced firing of medial vestibular nucleus neurons in a cat model of vertigo.{30249} Diphenidol (3.2 mg/kg, i.v.) prevents apomorphine-induced emesis in dogs.{30251} Formulations containing diphenidol have been used in the treatment of vertigo and as antiemetics.

• Artikelnummer: CAY33979-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33979-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung