Diprovocim-1, CAS 2170867-89-5

Diprovocim-1, CAS 2170867-89-5
Artikelnummer
CAY33174-1
Verpackungseinheit
1 mg
Hersteller
Cayman Chemical

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Formulation: A solid

Formal Name: (3S,3′S,4S,4′S)-1,1′-(1,4-phenylenedicarbonyl)bis[N-[(1S,2R)-2-phenylcyclopropyl]-3,4-pyrrolidinedicarboxamide

Purity: ≥98%

Formula Markup: C56H56N6O6

Formula Weight: 909,1

Shelf life (days): 1460

CAS Number: 2170867-89-5

Notes: Diprovocim-1 is an agonist of the toll-like receptor 1/2 heterodimer.{58429} It induces TNF-α release in THP-1 cells (EC50 = 110 pM), an effect that can be inhibited by anti-TLR1 or anti-TLR2 antibodies. Diprovocim-1 (10 mg/kg) increases the production of ovalbumin-specific IgG1 in wild-type, but not TLR2-/-, mice sensitized to ovalbumin.{58430} It also enhances anti-PD-L1 antibody-induced activation of cytotoxic T lymphocytes, reduction of tumor growth, and increases in survival in a B16/F10 murine melanoma model.
Mehr Informationen
Artikelnummer CAY33174-1
Hersteller Cayman Chemical
Hersteller Artikelnummer 33174-1
Green Labware Nein
Verpackungseinheit 1 mg
Mengeneinheit STK
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