Formulation: A solid
Formal Name: (3S,3′S,4S,4′S)-1,1′-(1,4-phenylenedicarbonyl)bis[N-[(1S,2R)-2-phenylcyclopropyl]-3,4-pyrrolidinedicarboxamide
Purity: ≥98%
Formula Markup: C56H56N6O6
Formula Weight: 909,1
Shelf life (days): 1460
CAS Number: 2170867-89-5
Notes: Diprovocim-1 is an agonist of the toll-like receptor 1/2 heterodimer.{58429} It induces TNF-α release in THP-1 cells (EC50 = 110 pM), an effect that can be inhibited by anti-TLR1 or anti-TLR2 antibodies. Diprovocim-1 (10 mg/kg) increases the production of ovalbumin-specific IgG1 in wild-type, but not TLR2-/-, mice sensitized to ovalbumin.{58430} It also enhances anti-PD-L1 antibody-induced activation of cytotoxic T lymphocytes, reduction of tumor growth, and increases in survival in a B16/F10 murine melanoma model.