DK-AH 269, CAS 186097-54-1

Formulation: A crystalline solid

Formal Name: 3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one, monohydrochloride

Purity: ≥98%

Formula Markup: C28H38N2O5 • HCl

Formula Weight: 519,1

Shelf life (days): 1460

CAS Number: 186097-54-1

Notes: DK-AH 269 blocks hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (IC50 = 0.62 µM in mouse sinoatrial node cells).{30118} DK-AH 269 slows heart rate by decreasing the spontaneous firing rate of the sinoatrial node in the heart.{33670} Using telemetric ECG recordings in mice, it reduced heart rate in a dose-dependent fashion with an ED50 of 1.2 mg/kg.{30118} DK-AH 269 also has proarrhythmic properties at concentrations higher than 5 mg/kg.{30118}

• Artikelnummer: CAY21425-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21425-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK