Dofetilide-d4, CAS 1189700-56-8

Formulation: A solid

Formal Name: N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl-1,1,2,2-d4]amino]ethyl]phenyl]-methanesulfonamide

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C19H23D4N3O5S2

Formula Weight: 445,6

Shelf life (days): 1460

CAS Number: 1189700-56-8

Notes: Dofetilide-d4 is intended for use as an internal standard for the quantification of dofetilide (Item No. 15045) by GC- or LC-MS. Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes).{24130} However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg.{24131} Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.{24132}

• Artikelnummer: CAY26451-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26451-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung