Dolasetron, CAS 115956-12-2

Formulation: A crystalline solid

Formal Name: 1H-indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, stereoisomer

Purity: ≥98%

Formula Markup: C19H20N2O3

Formula Weight: 324,4

Shelf life (days): 1460

CAS Number: 115956-12-2

Notes: Dolasetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 20 nM).{40077} It is selective for 5-HT3 receptors over 5-HT1A, 5-HT1B, 5-HT2, dopamine D2, α1-, α2-, β-adrenergic, M1-5 muscarinic acetylcholine, and neurokinin-1 (NK1) receptors (IC50s = >10 µM for all).{63099} Dolasetron inhibits 5-HT-induced membrane currents in NG 108-15 cells (IC50 = 3.8 nM).{40077} It increases the latency to emesis and reduces the number of vomiting and retching episodes induced by cisplatin (Item No. 13119) in ferrets when administered at doses of 0.5 or 2 mg/kg.{63099} Formulations containing dolasetron have been used in the prevention of postoperative or chemotherapy-induced nausea.

• Artikelnummer: CAY22234-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22234-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK