Dolasetron-d4

Formulation: A solid

Formal Name: 1H-indole-3-carboxylic acid-4,5,6,7-d4, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, stereoisomer

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C19H16D4N2O3

Formula Weight: 328,4

Shelf life (days): 1460

Notes: Dolasetron-d4 is intended for use as an internal standard for the quantification of dolasetron (Item No. 22234) by GC- or LC-MS. Dolasetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 20 nM).{40077} It is selective for 5-HT3 receptors over 5-HT1A, 5-HT1B, 5-HT2, dopamine D2, α1-, α2-, and β-adrenergic, M1-5 muscarinic acetylcholine, and neurokinin-1 (NK1) receptors (IC50s = >10 µM for all).{63099} Dolasetron inhibits 5-HT-induced membrane currents in NG 108-15 cells (IC50 = 3.8 nM).{40077} It increases the latency to emesis and reduces the number of vomiting and retching episodes induced by cisplatin (Item No. 13119) in ferrets when administered at doses of 0.5 or 2 mg/kg.{63099} Formulations containing dolasetron have been used in the prevention of postoperative or chemotherapy-induced nausea.

• Artikelnummer: CAY33294-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33294-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung