Domperidone-d6, CAS 1329614-18-7

Formulation: A solid

Formal Name: 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl-1,1,2,2,3,3-d6]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C22H18ClD6N5O2

Formula Weight: 432

Shelf life (days): 1460

CAS Number: 1329614-18-7

Notes: Domperidone-d6 is intended for use as an internal standard for the quantification of domperidone (Item No. 18875) by GC- or LC-MS. Domperidone is a dopamine D2 receptor antagonist (Ki = 0.3 nM in CHO cells expressing the rat receptor).{30683,53246} It is selective for dopamine D2 over D3 receptors (Ki = 9.5 nM).{30683} Domperidone (0.5-5 µg/kg) inhibits dipropyl dopamine-induced femoral vasodilation in dogs, indicating dopamine D2 receptor antagonist activity, and has no effect on dopamine-induced vasodilation in the renal vascular bed in dogs when administered at doses up to 5 mg/kg, indicating a lack of activity at dopamine D1 receptors.{53246} Domperidone (0.5 mg/kg) prevents dopamine-induced decreases in gastric antral motility induced by pentagastrin (Item No. 28546) in dogs.{53247} It inhibits apomorphine-induced emesis in dogs (ED50 = 0.031 mg/kg, p.o.).{39860} Domperidone also increases serum levels of prolactin in male rats.{46567}

• Artikelnummer: CAY30152
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30152-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung