Doxazosin-d8 (hydrochloride), CAS 1219803-95-8

Formulation: A solid

Formal Name: [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl-2,2,3,3,5,5,6,6-d8](2,3-dihydro-1,4-benzodioxin-2-yl)-methanone, monohydrochloride

Purity: ≥99% deuterated forms (d1-d8)

Formula Markup: C23H17D8N5O5 • HCl

Formula Weight: 496

Shelf life (days): 1460

CAS Number: 1219803-95-8

Notes: Doxazosin-d8 is intended for use as an internal standard for the quantification of doxazosin (Item No. 18633) by GC- or LC-MS. Doxazosin is a non-selective antagonist of α1-adrenergic receptors (α1-ARs; Kis = 3.16, 1, and 3.98 nM for α1A-, α1B-, and α1D-ARs, respectively).{18268} It inhibits norepinephrine-induced contractions in isolated rat aortic rings and human prostate strips with pA2 values of 8.8 and 8.2, respectively. Doxazosin inhibits phenylephrine-induced increases in blood pressure and prostatic pressure in anesthetized dogs (pA2 = 7.5 for both). Formulations containing doxazosin have been used in the treatment of benign prostatic hyperplasia and hypertension.

• Artikelnummer: CAY30979-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30979-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung