Droloxifene, CAS 82413-20-5

Formulation: A crystalline solid

Formal Name: 3-[(1E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol

Purity: ≥98%

Formula Markup: C26H29NO2

Formula Weight: 387,5

Shelf life (days): 1460

CAS Number: 82413-20-5

Notes: Droloxifene is a non-steroidal selective estrogen receptor modulator (SERM) and derivative of tamoxifen (Item No. 13258).{54810} Droloxifene binds to the estrogen receptor (ER) in rabbit uterine homogenates (IC50 = 24 nM in a radioligand binding assay) and inhibits expression of an estrogen-dependent luciferase reporter induced by 17β-estradiol (Item No. 10006315; IC50 = 49.8 nM).{54811,54812} It inhibits 17β-estradiol-stimulated growth of MCF-7, ZR-75-1, and T47D human breast cancer cells in a concentration-dependent manner.{54813} Droloxifene (10 mg/kg) increases wet uterine weight in mice.{54814}

• Artikelnummer: CAY33406-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33406-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK